The study included a multi-generational (parent, children, grandparent) analysis of provincial administrative data. Families with evidence of substance-use during pregnancy were included in the “Exposed” group and compared to a matched control group in the following areas: demographics, socio-economic status, disease prevalence, and system usage. A policy analysis included a comprehensive literature review. Stakeholders (policymakers, frontline workers, academics, and persons with lived/living experience) were consulted in various capacities, such as issue identification and brainstorming policy responses that are needed in New Brunswick.